Kinase Screening and Profiling Services

Kinase Screening and Profiling Services

With more than two decades of experience in kinase drug discovery, Eurofins Discovery has developed the industry’s largest collection of biochemical and cell-based kinase assays, including our unique assays that allow rapid determination of kinome-wide compound potency and selectivity.
 
Working with our team provides you the benefit of screening your compounds against the largest panel of unique wild-type human kinases available, and enables you to make better-informed decisions about therapeutic opportunities and potential off-target liabilities that could be otherwise missed in smaller kinase panels. Coupled with the fastest turnaround time in the industry, Eurofins Discovery’s Kinase Screening and Profiling Services enable expeditious SAR analysis to advance those compounds with the highest chance of being clinically effective and safe – as quickly as possible.
 
We offer various platforms of biochemical and cell-based kinase assays that enable development of entire kinase drug discovery programs — from HTS screens to Hit-to-Lead and Lead Optimization. We can set up a complete screening cascade for efficient, rapid and affordable outcome programs, leading to the selection of potent and selective lead candidates targeting your kinases of interest.

Key Areas

KinaseProfiler is the gold-standard radiometric, luminescence and HTRF activity-based platform, trusted by leading pharmaceutical and biotechnology companies worldwide. It assesses kinase activity, selectivity, and supports early derisking.

The KINOMEscan screening platform employs a novel and proprietary active site-directed competition binding assay to quantitatively measure interactions between test molecules and 480+ kinase assays covering wild-type and disease-relevant mutations.

A broad and growing portfolio of over 500 recombinant protein drug targets including active, inactive, and unactivated kinases, but also phosphatases, and the largest available selection of disease-relevant mutants.

When standard catalog proteins and assays do not meet your specific needs, leverage our deep understanding of how to design, produce & purify active proteins to keep your program moving forward.

Access to an industry-leading portfolio of biochemical and cellular based assays, with the help of industry experts and global custom service teams across key scientific disciplines who are able to focus on your specific needs with deliverables matched to your project goals.

Features