Protein Science for drug discovery focuses on generating high‑quality recombinant proteins and understanding how they interact with drug candidates, providing essential insight for early discovery. Eurofins Discovery streamlines this process with a complete solution spanning protein development, analytics, biophysics, and structural biology to deliver clear, decision‑ready data.
End-to-end Protein Science Workflow
Our team delivers the scientific depth, data quality, and operational consistency needed to progress from early screening to structural insight and mechanism of action clarification with speed and confidence.
Why choose Eurofins Discovery for Protein Science service?
Partnering with our Protein Science team helps you:
- Generate functional, biologically relevant recombinant proteins
- Identify new binders using advanced biophysical screening
- Clarify allosteric and novel mechanisms
- Reduce risk and accelerate timelines with data driven workflows
The Eurofins Discovery team delivers the quality and reproducibility required for complex target-based discovery programs. Challenging membrane targets such as GPCR, Ion Channels or Transporters are now within reach with recent Eurofins Calixar expertise.
The challenges we help you overcome during your drug discovery process
Drug discovery teams trust Eurofins Discovery to resolve:
- Long timelines caused by fragmented workflows
- Membrane protein functionality and stability challenges
- Inconsistent activity or binding data
- Repetitive construct optimization cycles
- Limited access to advanced biophysical or structural platforms
- Difficulty identifying binders for complex or novel targets
What you gain from our Protein Science services?
Our capabilities include:
- Custom protein development (soluble and membrane proteins)
- Advanced protein analytics
- Biophysical interaction studies (SPR, MST, TSA, ITC, HT Spectral Shift)
- Structural biology support (Cryo EM and X ray)
- Decision ready datasets through FFS or FTE models
Additional advantages:
- +90% Success rate across 15 years of challenging targets
- Reliable, reproducible datasets for biophysics and structural studies
- Support for structure-guided medicinal chemistry
- Accelerated hit identification via fragment and High-throughput Spectral Shift (HT-SpS) screening
We also offer prevalidated, of-the-shelf DiscoverX® proteins including kinases, helicases, phosphatases, epigenetic proteins, E3 ligases, GPCRs and more.
Eurofins Discovery’s Proven Track Record
Consult our case studies to learn how we approach fragment-based screening through advanced Protein Science, CryoEM–enabled 3D structural analysis or ternary complex characterization for kinase targets using biophysical techniques.
FAQ
- Q: What is Protein Science?
- A: Protein science is the study of protein structure, dynamics, function, and interactions at the molecular level. It integrates biophysical, biochemical, and computational methods to characterize proteins, enabling target validation, mechanism elucidation, and structure-guided drug design in preclinical research.
- Q: Why are high‑quality proteins essential for early drug discovery?
- A: High-quality proteins – properly folded, pure, and biologically active – are critical for reliable target validation, accurate biophysical and biochemical assays, and reproducible structure-guided drug design. Impurities or misfolded proteins can lead to false hits, misleading SAR data, and costly failures in preclinical development.
- Q: How does Eurofins Discovery support end‑to‑end Protein Science workflows?
- A: Eurofins Discovery provides an end-to-end Protein Science workflow fully supported by an expert team of PhDs. From Protein design and development, specific analytics, biophysics characterization to structural biology, our milestone driven workflow enables customized solutions.
- Q: What types of proteins can Eurofins Discovery produce?
- A: We can develop all classes of soluble and membrane-bound proteins, including GPCRs, ion channels, and transporters. Our proteins are developed in their most native conformation and folding, with full-length structure preservation and with verified biological activity and stability.
- Q: How does Eurofins Discovery help with membrane protein challenges?
- A: Recently acquired Calixar proprietary solutions, represent an advanced approach to challenging membrane proteins. Eurofins Discovery is now able to offer a diversified approach to protein solubilization and stabilization from synthetic nanodiscs, SMA polymers, proprietary detergents, and countless strategies tailored to your unique project.
- Q: How does working with a specialized CRO in Protein Science support drug discovery?
- A: A specialized CRO in Protein Sciences provides expertise in protein expression, purification, and characterization, enabling high-quality targets for assays and structural studies. This accelerates target validation, structure-based drug design, and reduces risk of experimental artifacts, improving the efficiency and reliability of early-stage drug discovery.
- Q: What are Eurofins Discovery’s typical timelines for Protein Science projects
- A: Most custom protein development projects are completed within 6–10 weeks, depending on target complexity, expression system, and downstream analytics or biophysical requirements.
- Q: Which biophysical technologies does Eurofins Discovery use, and what types of insights or data do these technologies provide?
- A: Biophysical technologies such as SPR, MST, ITC, high‑throughput Spectral Shift, TSA, nanoDSF, DLS, and mass spectrometry enable direct measurement of molecular binding, providing high‑confidence data including KD, Kon/Koff, and Kinact when relevant. These methods offer clear, mechanism‑oriented insights by distinguishing true binding events, resolving allosteric versus orthosteric interactions, and identifying compounds that disrupt protein–protein interactions, ensuring robust hit validation.
