Find Your Best Candidate Molecule by Assessing Temperature Stability Early

Large molecules such as proteins are exquisitely sensitive to changes in temperature. The melting temperature at which large molecules unfold can indicate the best temperatures for usage and storage as well as indicate which candidates are too unstable to move forward without modification.
 
At Eurofins Discovery, we can perform high throughput screens for melt temperature (T_m) of large molecules, as well as assessing the temperature of aggregation (T_agg). Unfolded or “sticky” proteins are prone to aggregation, which can mean they are unsuitable for large-scale production or testing.
 
Measuring T_m and T_agg under different conditions can indicate which lead molecules are too fragile for more rigorous testing and manufacturing conditions.
 
With our state-of-the-art technical capabilities including our microfluidic instruments, this crucial testing can be quick and will require far less material than traditional stability testing.