D1 Human Dopamine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR

Background Information:

Dopamine receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Various members of the dopamine receptor family are generally classified as either ‘D1-like’ or ‘D2-like’. D1-like receptors comprise the D1 and D5 receptors, which activate adenylate cyclases via coupling to GS protein.

Family:

GPCR

Sub Family:

Dopamine

Class:

Class A

Protein Name:

D1

Uniprot Number:

P21728

Protein Aliases:

Dopamine D1 receptor

Gene Name:

DRD1

Gene ID:

1812

Accession Number:

NM_000794

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1