PBR Human Binding Antagonist Radioligand LeadHunter Assay - FR

Background Information:

Translocator protein (TSPO), previously called peripheral benzodiazepine receptor (PBR), was originally discovered as an alternative binding site for diazepam, a benzodiazepine. PBR/TSPO is a multimeric receptor composed of the Mr 18,000 receptor protein and the Mr 34,000 voltage-dependent anion channel protein. Expression of PBR has been found in every tissue examined; however, it is most abundant in steroid-producing tissues such as the adrenals, testes, ovaries, placenta, and brain, where it is primarily localized in the outer mitochondrial membrane. The primary function of PBR is the regulation of steroidogenesis, its existence in nonsteroidogenic tissues suggests that there may be other roles for PBR.

Family:

Mitochondrial Function

Sub Family:

Mitochondrial-Associated Protein

Protein Name:

PBR

Uniprot Number:

B1AH88|P30536

Protein Aliases:

peripheral-type benzodiazepine receptor/recognition site

Gene Name:

TSPO

Gene ID:

706

Gene Aliases:

PBR|MBR|PKBS|mDRC|DBI|IBP|pk18

Accession Number:

NM_007311

Organism:

Human