5-HT1A Human Serotonin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - FR

Background Information:

Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The 5-HT1 receptor class couples preferentially to Gi/Go to inhibit cAMP formation. Serotonin 5-HT1A receptors are widely distributed in the central nervous system as well as in the periphery.

Family:

GPCR

Sub Family:

Serotonin

Class:

Class A

Protein Name:

5-HT1A

Uniprot Number:

P08908

Protein Aliases:

5-HT1A|G-21|Serotonin receptor 1A

Gene Name:

HTR1A

Gene ID:

3350

Gene Aliases:

ADRB2RL1|ADRBRL1

Organism:

Human

Construct Details:

Recombinant

Cell Type:

BA/F3