MC4 Human Melanocortin GPCR Cell Based Agonist cAMP LeadHunter Assay - FR

Background Information:

Melanocortins belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The melanocortin MC1 receptor is made primarily in melanocytes, MC2 in adrenal cortex, MC3 and MC4 almost exclusively neuronal, and MC5 in exocrine gland cells.

Family:

GPCR

Sub Family:

Melanocortin

Class:

Class A

Protein Name:

MC4

Uniprot Number:

P32245

Gene Name:

MC4R

Gene ID:

4160

Accession Number:

NM_005912

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1