MKK7 (MAP2K7) Human Kinase STE Enzymatic [Km ATP] SafetyScreen - FR

Background Information:

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE.

Family:

Kinase

Sub Family:

STE

Class:

Protein Ser/Thr

Protein Name:

MAPKK 7

Uniprot Number:

O14733

Protein Aliases:

JNK-activating kinase 2; MAPK/ERK kinase 7 (MEK 7); Stress-activated protein kinase kinase 4 (SAPK kinase 4; SAPKK-4; SAPKK4);c-Jun N-terminal kinase kinase 2 (JNK kinase 2; JNKK 2)

Gene Name:

MAP2K7

Gene ID:

5609

Gene Aliases:

JNKK2, MEK7, MKK7, PRKMK7, SKK4

Accession Number:

NM_145185.4

Organism:

Human