Tyrosine Hydroxylase Rat Enzymatic LeadHunter Assay - FR

Background Information:

Tyrosine hydroxylase (tyrosine-3-monooxygenase, tyrosine oxidase, E.E.1.14.13.41) which catalyzes the hydroxylation of tyrosine is generally regarded as a rate-limiting step in the biosynthesis of catecholamines. The enzyme is activated following stimulation of adrenergic nerves or the adrenal medulla. Tyrosine hydroxylase is a substrate for cyclic AMP-dependent kinase, and kinase-catalyzed phosphorylation is associated with increased hydroxylase activity. The enzyme is also a substrate for Ca2+-activated protein kinases. In addition, tyrosine hydroxylase is inhibited by catechol compounds in a manner that is competitive with its pterin cofactor, tetrahydrobiopterin. It is thus subject to end-producr feedback inhibition. A potent and selective inhibitor of this enzyme may prove useful as a therapeutic agent in the treatment of hypertension as well as schizophrenia and tardive dyskinesia.

Family:

Neurotransmitter Metabolism

Sub Family:

Amino Acid Hydroxylase

Protein Name:

Tyrosine Hydroxylase

Uniprot Number:

P07101

Protein Aliases:

tyrosine 3-monooxygenase

Gene Name:

TH

Gene ID:

7054

Gene Aliases:

DYT5b

Accession Number:

NM_000360

Organism:

Rat

Tissue:

Brain