5-HT4E Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - FR

Background Information:

Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Serotonin 5-HT4 receptors are widely distributed in the central nervous system and peripheral tissues. The 5-HT4 receptor class couples preferentially to GS to promote cAMP formation.

Family:

GPCR

Sub Family:

Serotonin

Class:

Class A

Protein Name:

5-HT4

Uniprot Number:

Q13639

Gene Name:

HTR4

Gene ID:

3360

Gene Aliases:

5-HT4

Accession Number:

NM_000870

Organism:

Human

Construct Details:

Recombinant