Biological Information

Family:

GPCR

Sub Family:

Cannabinoid

Class:

Class A

Protein Name:

CB1

Uniprot Number:

P21554

Gene Name:

CNR1

Gene ID:

1268

Gene Aliases:

CB1K5|CB-R|CB1|CANN6|CB1A

Accession Number:

X54937

Organism:

Human

Construct Details:

Recombinant

Assay Information

Assay Type:

Biochemical

Assay Sub Type:

Binding

Detection Method:

Radiometric

Measured Response:

Scintillation

Testing Information

Ligand:

[3H]CP 55940

Ligand Kd (nM):

0.9

Ligand Concentration:

2 nM

Non Specific:

AM281 (10 µM)

Incubation:

30 min at RT

Control Inhibitor:

CP55940

Test Concentration / Dose:

Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.

Test Sample Requirements:

Minimum for 1) Screen: 60 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing. 2) Dose Response: 90 μl of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.

Minimum Order Quantity:

2

Turnaround Time

Standard:

10 Business Days

Reference Compound Data

PubChem ID

104849

Name

Rimonabant hydrochloride

Measurement

2nM - IC50

PubChem ID

104895

Name

CP55940

Measurement

2.9nM - IC50

PubChem ID

4302962

Name

AM 281

Measurement

5.9nM - IC50

PubChem ID

24278779

Name

WIN 55212-2

Measurement

74nM - IC50

Clinical Relevance

Therapeutic Area:

CNS/Addiction/Pain

Additional Information

Brand:

LeadHunter

Testing Location:

France - Celle L'Evescault

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