mGlu5 Human Glutamate (Metabotropic) GPCR Binding Agonist Radioligand LeadHunter Assay - FR

Background Information:

Glutamate is the major excitatory transmitter in the mammalian central nervous system. The receptor amino acid sequences lie in the same superfamily as GABA, glycine, serotonin 5-HT3 and nicotinic acetylcholine, within the general class of ligand-gated ion channels. Glutamate receptors are classified functionally as ligand-gated ion channels (“ionotropic”) or as “metabotropic” receptors (mGluR) coupled via GTP-binding proteins. The eight known members of the mGluR subfamily have been divided into three groups on the basis of their sequence identity, pharmacology, and preferred signal transduction mechanism. Group I (mGluRs 1 and 5) signal through inositol phospholipid breakdown whereas Group II (mGluRs 2 and 3) and Group III (mGluRs 4, 6 ,7 and 8) inhibit adenylyl cyclase.

Family:

GPCR

Sub Family:

Glutamate (Metabotropic)

Class:

Class C

Protein Name:

mGlu5

Uniprot Number:

P41594

Protein Aliases:

protein phosphatase 1, regulatory subunit 86

Gene Name:

GRM5

Gene ID:

2915

Gene Aliases:

MGLUR5|GPRC1E|mGlu5|PPP1R86

Accession Number:

NM_000842

Organism:

Human

Construct Details:

Recombinant