ADME & Toxicology Services

ADME & Toxicology Services

Helping you accelerate drug candidate selection. Eurofins Discovery has empowered thousands of partner organizations over the last two decades to rapidly and efficiently evaluate ADME and toxicology properties, helping propel promising drug candidates through preclinical and clinical development.
 
Performing early in vitro screening to better understand the Absorption, Distribution, Metabolism, and Excretion (ADME) and Pharmacokinetics (PK) properties of your compounds is essential for selecting candidates with desirable profiles. Likewise, assessing potential compound-mediated toxicities in the early phases of drug discovery can help reduce drug attrition during later phases of development.
 
Accurate and reliable ADME and toxicology testing, available at any stage in your search through Eurofins Discovery, can enhance your decision-making process, reduce costs and timelines, and enable you to confidently choose the best drug candidates to move forward into development.
 
As a leading specialist in nonclinical ADME and Toxicology Services for over 25 years, Eurofins Discovery focuses on providing cost-effective, reproducible, high-quality data for our clients. With over 600 assays, our fast turn-around times, flexibility, and commitment to your project, we can deliver high-quality results to meet your specific project needs.
 
Graphic Depicting The Key Market Differentiators, including: Over 600 ADME & Tox Assays, Fast Results with 3-5 day TAT’s, Trusted by over 2,000 clients, 25+ years expertise, Millions of data points per year, Tailored solutions to fit your project needs, and Industry Competitive Pricing.
 

Early ADME

Quickly assess compound PK properties with rapid TATs for compound solubility, permeability, protein binding, intrinsic clearance and lipophilicity assays
 

Mid-stage ADME

Narrow down promising leads with a comprehensive selection of ADME services; bioanalytical support, metabolism and metabolite profiling, CYP and transporter screening, and more
 

IND-Enabling ADME

Obtain drug metabolism, transporter, and drug-drug interaction data to satisfy regulatory requirements and advance promising lead candidates into clinical development
 

Early In Vitro Toxicology

Predict the likelihood for compound-mediated toxicities early in drug discovery with high-throughput screening for hepatotoxicity, cardiotoxicity, genotoxicity, cytotoxicity and renal toxicity.
 

Mid-to-Late-Stage In Vitro Toxicology

Investigate potential adverse effects to gain a better understanding of what to expect in preclinical testing utilizing specialized toxicology assays, BioMAP® platform and Safety Pharmacology services
 

In Vivo DMPK and Safety Assessment

Pharmacology Discovery Services, a partner lab of Eurofins Discovery, has over 30 years of experience conducting in vivo non-GLP preclinical pharmacokinetics (PK), and safety and toxicology evaluations for drug discovery. For more information visit: PharmacologyDiscoveryServices.com
 
Diagram showing which ADME-Tox services correspond to which pre-clinical drug discovery workflow stage
Partner with Eurofins Discovery today. Our ADME & Toxicology solutions combine deep scientific expertise, advanced analytical technologies, and flexible study designs empowering thousands of partner organizations to rapidly and efficiently advance promising drug candidates through drug discovery and preclinical development.
 
Contact us today to discuss your study design and discover how our ADME & Toxicology services can accelerate your next breakthrough.
 
 

Key Areas

End-to-end solutions for in vitro ADME testing, including bioavailability assays, metabolic profiling, stability, and metabolite identification, CYP450 inhibition and induction assays, drug transporters, and more.

Comprehensive in vitro toxicology services provide an extensive characterization of potential compound liabilities due to cardiac safety, hepatotoxicity, genotoxicity, safety pharmacology, and more.

Hepatotoxicity is one of the major causes of failure during drug development and the major reason for removal of approved drugs from the market.

Identify potential tissue-relevant toxicity (cytotoxicity) earlier in the in vitro development process using a sensitive in vitro, image-based high content analysis approach.

Test kidney cellular stress and injury using multiplexed nephrotoxicity assays, to help you to uncover liabilities earlier in the discovery process.

Our technical experts and partner lab can customize in vivo testing for your specific study design or disease model, creating an efficient process that propels you closer to the clinic.

Develop Safer Preclinical Candidates with Industry-leading, Reliable and Robust In Vitro Safety Assays and Panels

Confidently select candidates for clinical trials with predictive human toxicity signatures.

Investigate ion channel targets and/or assess drug safety profiles early in the drug discovery process.

Our SAFIRE technology combines the power of AI with high-quality Eurofins Discovery proprietary data to supercharge drug discovery.

FAQs

You can use our search function in the upper right-hand corner of the screen to search for specific assays or click the view assays button on each ADME-Tox page. If you want to see the specific ADME or toxicology assays we offer, you can click the links in the “Key Areas” section above.

Yes, we can tailor our panels or assay protocols to your specific needs. Our extensive portfolio and cross-discipline bench of expertise has expanded and strengthened our capabilities in custom-designed assays. The easiest way to see how we can fit your needs is to contact us and speak with our technical experts.

We proudly offer e-commerce capabilities to our customers. In addition, we have client service representatives available to help you promptly place orders.

Please sign in to your online account or create a new online account at https://apac.eurofinsdiscovery.com/usermanagement/login

You can easily get in touch with a Eurofins Discovery ADME-Tox Expert or get help from our Customer Service team. Reach out with questions, or to discuss your specific discovery challenges by visiting: https://apac.eurofinsdiscovery.com/usermanagement/customer-service

We provide competitive pricing models based on our client’s specific project needs. Our pricing models include standard pricing, custom pricing, loyalty-based pricing, and project specific pricing. If you have further questions about pricing for your ADME-Tox project, please reach out to your Eurofins Discovery business development partner or client services to discuss your pricing needs in more detail.

We do offer rapid TAT’s of 3 to 5 business days for many of the early ADME assays. However, our turnaround times vary by the type of assay requested. The TAT’s for all of our assays can be found on the individual assay detail web pages (please use the search bar on our web page to find details for specific assays).

We have a strong track record of success resulting in the delivery of 40+ IND candidates and 5 commercialized drugs. We’ve also been named inventors and authors on over 300 patents and publications.

Eurofins Discovery’s drug discovery expert teams, advanced technologies, and seamless integration of chemistry, biology, ADME, Toxicology, and pharmacology capabilities set us apart from traditional fragmented offerings—delivering rapid innovation, cost efficiency, and robust IP generation.

Our ADME-Tox resource guides, as well as other valuable resources, can be found on the Eurofins Discovery Resources web page: https://apac.eurofinsdiscovery.com/resources

Our two most popular ADME-Tox resource guides include the Drug Candidate Assessment Resource Guide and the Drug-Drug Interaction Resource Guide. These are available on our resources page.

Yes, but for this purpose the standard final report would require some enhancements, such as: conclusion/interpretation of results, discussion of unusual findings, additional experimental details, validation data, lot numbers and Certificates of Analysis of hepatocytes, enzymes, etc., used in the study and a pre-quote discussion with the client is useful to define deliverables required in the custom report.

Questions? Contact Us

You can easily get in touch with a Eurofins Discovery Expert or get help from our Customer Service team. Reach out with questions, or to discuss your specific discovery challenges.

Questions? Contact Us