Biological Information

Background Information:

Panel of two BioMAP systems incorporating colorectal adenocarcinoma cells and stimulated to recapitulate and model tumor-immune-stromal or tumor-immune-vascular microenvironments and relevant signaling pathways that manifest during tumorigenesis. The StroHT29 system is comprised of dermal fibroblasts, the HT-29 colorectal adenocarcinoma cell line, and peripheral blood mononuclear cells to model to stromal tumor microenvironment. The VascHT29 system is comprised of venular endothelial cells, the HT-29 colorectal adenocarcinoma cell line, and peripheral blood mononuclear cells to model the vascular tumor microenvironment.

No. of Assays on Panel:

2

Assays on Panel:

Family

Name

Item

89-0003-0045

Protein

Organism

Human

Assay Sub Type

Cell Based

Family

Name

Item

89-0003-0046

Protein

Organism

Human

Assay Sub Type

Cell Based

Organism:

Human

Assay Information

Assay Type:

Functional

Assay Sub Type:

Cell Based

Testing Information

Test Concentration / Dose:

Four concentrations per test agent in triplicate

Test Sample Requirements:

For Small Molecules: 120uL of a 1000X stock based on the top concentration being tested & standard 3-fold dilutions. For Biologics: 1.2mL of a 100X stock in PBS or water, based on the top concentration being tested & standard 3-fold dilutions

Turnaround Time

Standard:

40 Business Days

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology

Additional Information

Brand:

BioMAP

Testing Location:

USA - St Charles, MO

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