OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
This panels evaluates the most commonly screened kinases identified as safety-associated targets by the IQ DruSafe In vitro Secondary Pharmacology Working Group (Brennan, R.J., et al. Nat Rev Drug Discov, 2024) in a physiological environment following the latest recommendations.
No. of Assays on Panel:
19
Assays on Panel:
Family
Kinase
Name
ATM Human PIKK Kinase Enzymatic [1mM ATP] SafetyScreen - FR
Item
5891
Protein
ATM
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-A (AURKA) Human Other Protein Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5892
Protein
Aurora-A
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-B (AURKB) Human Other Protein Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5893
Protein
Aurora-B
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
c-Kit Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5894
Protein
Kit
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
CLIK (STK35) Human Other Protein Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5895
Protein
CLIK
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
EGFR Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5896
Protein
EGFR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FAK Human TK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5897
Protein
FAK
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
TRKA Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5898
Protein
TRKA
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FGFR1 Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5899
Protein
FGFR1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Src Human TK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5900
Protein
Src
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK2 Human AGC Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5901
Protein
ROCK2
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK1 Human AGC Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5902
Protein
ROCK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Flt-1 (VEGFR1) (FLT1) Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5903
Protein
Flt-1 (VEGFR1)
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
PI3Kgamma (PIK3CG) (p120gamma) Human PtdIns(4,5)P 3-Kinase Enzymatic [1mM ATP] SafetyScreen - FR
Item
5904
Protein
PI3Kgamma
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
GSK3beta (GSK3B) Human CMGC Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5905
Protein
GSK3beta
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
KDR (VEGFR2) (KDR) Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5906
Protein
KDR (VEGFR2)
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
IR (INSR) Human RTK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5907
Protein
IR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Lck Human TK Kinase Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5911
Protein
Lck
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
PDHK1 (PDK1) Human Kinase Other protein Enzymatic Radiometric [1mM ATP] SafetyScreen - FR
Item
5925
Protein
PDK1
Organism
Human
Assay Sub Type
Enzymatic
Family:
Kinase
Testing Information
Test Sample Requirements:
Minimum for Screen: 100 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10 µM final testing.
(PBS or HBSS working solutions are not compatible)
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
KP - France - Celle L'Evescault
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