Nav1.5 Sodium Channel Human Ion Channel [3H]BNZA Binding LeadHunter Assay - TW

Background Information:

Nav1.5 is the predominant voltage-gated sodium channel expressed in cardiomyocytes and is encoded by the SCN5A gene. Structurally, Nav1.5 consists of a pore-forming α-subunit containing four homologous domains with six transmembrane segments each. It mediates the rapid inward sodium current responsible for depolarization of the cardiac action potential, playing a critical role in cardiac excitability and impulse conduction. Pathogenic variants in SCN5A can either increase or decrease Nav1.5 channel activity, disrupting cardiac electrical conduction and giving rise to a spectrum of inherited arrhythmia syndromes, including Long QT Syndrome, Brugada syndrome, sick sinus syndrome, and cardiac conduction disease. Due to its essential role in cardiac electrophysiology and safety pharmacology, Nav1.5 is a key target in cardiovascular risk assessment and drug discovery.

Family:

Ion Channel

Sub Family:

Sodium

Class:

Voltage-Gated

Protein Name:

Nav1.5

Uniprot Number:

Q14524

Protein Aliases:

Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5

Gene Name:

SCN5A

Gene ID:

6331

Organism:

Human