GPBA (TGR5) Human Bile acid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Evaluation of the affinity of compounds for the human bile acid GPBA receptor in transfected CHO cells determined in a radioligand binding assay.
Family:
GPCR
Sub Family:
Bile Acid
Class:
Class A
Protein Name:
GPBA receptor
Uniprot Number:
Q8TDU6
Protein Aliases:
G-protein coupled receptor GPCR19 (hGPCR19)
Gene Name:
GPBAR1
Gene ID:
151306
Gene Aliases:
BG37; TGR5; M-BAR; GPCR19; GPR131
Organism:
Human
Assay Information
Assay Type:
Biochemical
Assay Sub Type:
Binding
Detection Method:
Scintillation counting
Testing Information
Ligand:
[3H]TC-G 1005
Ligand Concentration:
5 nM
Non Specific:
TC-G 1005 (10µM)
Incubation:
360 min at 22 °C
Test Sample Requirements:
Minimum for 1) Screen: 60 µl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing. 2) Dose Response: 90 µl of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
2
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
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