OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Evaluation of two compounds in any BioMAP system, individually and in combination. The BT system is comprised of peripheral blood mononuclear cells and B cells. It models the T cell dependent B cell proliferation, activation, and class switching that occurs in the germinal centers of secondary lymphoid organs. The BT system is relevant for indications in which B cell activation and antibody production have been implicated including systemic lupus erythematosus (SLE), hematological oncology, autoimmune indications, asthma, and allergy.
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Concentration / Dose:
Two test agents profiled alone at four concentrations, and in combination in a four-by-four matrix, in triplicate.
Test Sample Requirements:
For Small Molecules: 350uL of a 1000X stock based on the top concentration being tested & standard 3-fold dilutions per system and per Combo. For Biologics: 3.5mL of a 100X stock in PBS or water, based on the top concentration being tested & standard 3-fold dilutions per system and per Combo
Turnaround Time
Standard:
40 Business Days
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
BioMAP
Testing Location:
USA - St Charles, MO
RELATED SOLUTIONS
Autoimmune Activation Model/Th17 Panel (PBMC)
Item: 960090
T-Cell Inflammation Inhibition (PBMC)
Item: 960010
T-Cell Inflammation Stimulation (PBMC)
Item: 960011
TLR1 /TLR2 Human TLR Cell Based Agonist Assay in PBMC
Item: 960031
TLR1 /TLR2 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960036
TLR2 /TLR6 Human TLR Cell Based Agonist Assay in PBMC
Item: 960032
TLR2 /TLR6 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960037
TLR4 Human TLR Cell Based Agonist Assay in PBMC
Item: 960033
TLR4 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960038
TLR7 /TLR8 Human TLR Cell Based Agonist Assay in PBMC
Item: 960034
TLR7 /TLR8 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960039
TLR9 Human TLR Cell Based Agonist Assay in PBMC
Item: 960035
TLR9 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960040
BioMAP Diversity PLUS
Item: 89-0001-0903
BioMAP Systems ELECT Menu 3 (BT)
Item: 89-0003-0005
BioMAP T Cell Autoimmune Panel
Item: 89-0014-0905
BioMAP Combo ELECT Menu 3 (BTNo)
Item: 89-0015-0014
T Cell Inflammation Inhibition Assay in Human PBMCs (1 donor)
Item: 960010-01
T Cell Inflammation Stimulation Assay in Human PBMCs (1 donor)
Item: 960011-01
TLR1/TLR2 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960031-01
TLR2/TLR6 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960032-01
TLR4 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960033-01
TLR5 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960041-01
TLR9 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960035-01
TLR1/TLR2 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960036-01
TLR2/TLR6 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960037-01
TLR4 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960038-01
TLR5 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960042-01
TLR7/TLR8 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960039-01
TLR9 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960040-01
Autoimmune Activation Model/Th17 Panel in Human PBMCs (1 donor)
Item: 960090-01
TLR7/TLR8 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960034-01
Questions? Contact Us
You can easily get in touch with a Eurofins Discovery Expert or get help from our Customer Service team. Reach out with questions, or to discuss your specific discovery challenges.
