OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Evaluation of two compounds in any BioMAP system, individually and in combination. The lTH2 system is comprised of venular endothelial cells and TH2 blasts. It models vascular inflammation (mixed Th1 and Th2 types) and permeability, and is a pro-angiogenic environment that promotes mast cell, basophil, eosinophil, T and B cell recruitment. The lTH2 system is relevant for diseases in which Th2-type inflammation plays a role such as allergy, asthma, and ulcerative colitis.
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Concentration / Dose:
Two test agents profiled alone at four concentrations, and in combination in a four-by-four matrix, in triplicate.
Test Sample Requirements:
For Small Molecules: 350uL of a 1000X stock based on the top concentration being tested & standard 3-fold dilutions per system and per Combo. For Biologics: 3.5mL of a 100X stock in PBS or water, based on the top concentration being tested & standard 3-fold dilutions per system and per Combo
Turnaround Time
Standard:
40 Business Days
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
BioMAP
Testing Location:
USA - St Charles, MO
RELATED SOLUTIONS
Autoimmune Activation Model/Th17 Panel (PBMC)
Item: 960090
T-Cell Inflammation Inhibition (PBMC)
Item: 960010
T-Cell Inflammation Stimulation (PBMC)
Item: 960011
TCR Inflammation Inhibition (Jurkat)
Item: 960070
TLR1 /TLR2 Human TLR Cell Based Agonist Assay in PBMC
Item: 960031
TLR1 /TLR2 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960036
TLR2 /TLR6 Human TLR Cell Based Agonist Assay in PBMC
Item: 960032
TLR2 /TLR6 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960037
TLR4 Human TLR Cell Based Agonist Assay in PBMC
Item: 960033
TLR4 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960038
TLR7 /TLR8 Human TLR Cell Based Agonist Assay in PBMC
Item: 960034
TLR7 /TLR8 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960039
TLR9 Human TLR Cell Based Agonist Assay in PBMC
Item: 960035
TLR9 Human TLR Cell Based Antagonist Assay in PBMC
Item: 960040
BioMAP Systems ELECT Menu 2 (lTH2)
Item: 89-0003-0034
BioMAP T Cell Autoimmune Panel
Item: 89-0014-0905
BioMAP Combo ELECT Menu 2 (lTH2No)
Item: 89-0015-0035
BioMAP RNA ELECT (lTH2)
Item: 89-0035-0034
T Cell Inflammation Inhibition Assay in Human PBMCs (1 donor)
Item: 960010-01
T Cell Inflammation Stimulation Assay in Human PBMCs (1 donor)
Item: 960011-01
TLR1/TLR2 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960031-01
TLR2/TLR6 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960032-01
TLR4 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960033-01
TLR5 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960041-01
TLR9 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960035-01
TLR1/TLR2 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960036-01
TLR2/TLR6 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960037-01
TLR4 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960038-01
TLR5 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960042-01
TLR7/TLR8 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960039-01
TLR9 Human TLR Cell Based Antagonist Assay in PBMCs (1 donor)
Item: 960040-01
Autoimmune Activation Model/Th17 Panel in Human PBMCs (1 donor)
Item: 960090-01
TLR7/TLR8 Human TLR Cell Based Agonist Assay in PBMCs (1 donor)
Item: 960034-01
TLR5 Human TLR Cell Based Agonist Assay in PBMCs
Item: 960041
Questions? Contact Us
You can easily get in touch with a Eurofins Discovery Expert or get help from our Customer Service team. Reach out with questions, or to discuss your specific discovery challenges.
