OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Evaluation of two compounds in any BioMAP system, individually and in combination. The SAg system is comprised of venular endothelial cells and peripheral blood mononuclear cells. It models Th1 type chronic inflammation and T cell effector responses related to T cell proliferation and activation in the context of the vascular endothelium. Modeling chronic inflammation of the Th1 type and T cell effector responses, the SAg system is relevant for T-cell driven inflammatory conditions including organ transplantation, rheumatoid arthritis, psoriasis, Crohn's disease, and hematological oncology.
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Concentration / Dose:
Two test agents profiled alone at four concentrations, and in combination in a four-by-four matrix, in triplicate.
Test Sample Requirements:
For Small Molecules: 350uL of a 1000X stock based on the top concentration being tested & standard 3-fold dilutions per system and per Combo. For Biologics: 3.5mL of a 100X stock in PBS or water, based on the top concentration being tested & standard 3-fold dilutions per system and per Combo
Turnaround Time
Standard:
40 Business Days
Clinical Relevance
Therapeutic Area:
Autoimmune
Additional Information
Brand:
BioMAP
Testing Location:
USA - St Charles, MO
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